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• 11. [Article] Emily Escobedo Research Poster 2013.pptx

  Citation × Citation Citation Abstract Copy Title: Emily Escobedo Research Poster 2013.pptx Author: Magnusson, K., Escobedo, Emily R. Title: Emily Escobedo Research Poster 2013.pptx Author: Magnusson, K., Escobedo, Emily R. Close

• 12. [Article] Emily Escobedo Research Poster 2013.pdf

  Citation × Citation Citation Abstract Copy Title: Emily Escobedo Research Poster 2013.pdf Author: Magnusson, K., Escobedo, Emily R. Title: Emily Escobedo Research Poster 2013.pdf Author: Magnusson, K., Escobedo, Emily R. Close

• 13. [Article] marquez loza final seminar.pdf

  Citation × Citation Citation Abstract Copy Title: marquez loza final seminar.pdf Author: Marquez Loza, Alejandra Title: marquez loza final seminar.pdf Author: Marquez Loza, Alejandra Close

• 14. [Article] Márquez.A.Thesis.pdf

  Citation × Citation Citation Abstract Copy Title: Márquez.A.Thesis.pdf Author: Marquez Loza, Alejandra Title: Márquez.A.Thesis.pdf Author: Marquez Loza, Alejandra Close

• 15. [Article] Do Stress Trajectories Predict Mortality in Older Men? Longitudinal Findings from the VA Normative Aging Study

  We examined long-term patterns of stressful life events (SLE) and their impact on mortality contrasting two theoretical models: allostatic load (linear relationship) and hormesis (inverted U relationship) ...

  Citation × Citation Citation Abstract Copy Title: Do Stress Trajectories Predict Mortality in Older Men? Longitudinal Findings from the VA Normative Aging Study Author: Aldwin, Carolyn M., Molitor, Nuoo-Ting, Igarashi, Heidi, Molitor, John, Spiro, Avron III, Levenson, Michael R. We examined long-term patterns of stressful life events (SLE) and their impact on mortality contrasting two theoretical models: allostatic load (linear relationship) and hormesis (inverted U relationship) in 1443 NASmen (aged 41–87 in 1985; M = 60.30, SD = 7.3) with at least two reports of SLEs over 18 years (total observations = 7,634). Using a zero-inflated Poisson growth mixture model, we identified four patterns of SLE trajectories, three showing linear decreases over time with low, medium, and high intercepts, respectively, and one an inverted U, peaking at age 70. Repeating the analysis omitting two health-related SLEs yielded only the first three linear patterns. Compared to the low-stress group, both the moderate and the high-stress groups showed excess mortality, controlling for demographics and health behavior habits, HRs = 1.42 and 1.37, ps < .01 and < .05. The relationship between stress trajectories and mortality was complex and not easily explained by either theoretical model. Title: Do Stress Trajectories Predict Mortality in Older Men? Longitudinal Findings from the VA Normative Aging Study Author: Aldwin, Carolyn M., Molitor, Nuoo-Ting, Igarashi, Heidi, Molitor, John, Spiro, Avron III, Levenson, Michael R. We examined long-term patterns of stressful life events (SLE) and their impact on mortality contrasting two theoretical models: allostatic load (linear relationship) and hormesis (inverted U relationship) in 1443 NASmen (aged 41–87 in 1985; M = 60.30, SD = 7.3) with at least two reports of SLEs over 18 years (total observations = 7,634). Using a zero-inflated Poisson growth mixture model, we identified four patterns of SLE trajectories, three showing linear decreases over time with low, medium, and high intercepts, respectively, and one an inverted U, peaking at age 70. Repeating the analysis omitting two health-related SLEs yielded only the first three linear patterns. Compared to the low-stress group, both the moderate and the high-stress groups showed excess mortality, controlling for demographics and health behavior habits, HRs = 1.42 and 1.37, ps < .01 and < .05. The relationship between stress trajectories and mortality was complex and not easily explained by either theoretical model. Close

• 16. [Article] A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects of aging on spatial reference memory

  A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling ...

  Citation × Citation Citation Abstract Copy Title: A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects of aging on spatial reference memory Author: Magnusson, K., Escobedo, Emily R. A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 Humans and rodents experience declines in reference (long-term), working (short-term) memory, and cognitive flexibility during the aging process. Aging changes in GluN1 and GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor subunit expression in rats. The hypothesis addressed in the present study was that inflammation plays a role in NMDA receptor aging and memory declines. The question addressed was whether a pro-inflammatory treatment in young mice would produce the same changes in memory and NMDA receptor expression as aging. Male C57BL/6 mice (3 month old) were randomly assigned to 2 treatment groups, lipopolysaccharide (LPS) or saline. Non-surgical (24 month old) mice were also included. Cannulas attached to osmotic pumps were implanted into the lateral ventricles of the brain for 3 weeks. One week after pumps were removed, behavioral testing was performed with the Morris water maze. LPS-treated young (cumulative proximity (cm): 6287 ± 625; RANOVA & Fisher’s LSD) performed significantly worse than saline young (Mean: 4565 ± 352) and similar to old mice (Mean: 7519 ± 389) in reference memory place trials. LPS treated young (average proximity (cm): 40 ± 1.4) performed similar to saline young (35 ± 1.3), and old (45± 1.5) performed the poorest in probe trials for reference memory. LPS didn’t appear to have any effect on reversals, working memory, or cued trials. The average swim speed for reference memory and cued trials showed that the LPS treated were the fastest swimmers, presenting that any deficits were not due to poor motor ability. Stimulating inflammation in a young brain produced only some of the memory deficits seen in aging. Supported by NIH grant AG016322 to K.R.M. Title: A pro-inflammatory agent, Lipopolysaccharide, can mimic the effects of aging on spatial reference memory Author: Magnusson, K., Escobedo, Emily R. A pro-inflammatory agent, lipopolysaccharide, can mimic the effects of aging on spatial reference memory E. R. ESCOBEDO and K. R. Magnusson, Dept. of Biomedical Sciences, Coll. of Vet. Med., Linus Pauling Institute, Oregon State University, Corvallis, OR 97331 Humans and rodents experience declines in reference (long-term), working (short-term) memory, and cognitive flexibility during the aging process. Aging changes in GluN1 and GluN2B subunits of N-methyl-D-aspartate (NMDA) receptors show a relationship to both reference and working memory deficits. Sulindac, an anti-inflammatory drug, enhances working memory and NMDA receptor subunit expression in rats. The hypothesis addressed in the present study was that inflammation plays a role in NMDA receptor aging and memory declines. The question addressed was whether a pro-inflammatory treatment in young mice would produce the same changes in memory and NMDA receptor expression as aging. Male C57BL/6 mice (3 month old) were randomly assigned to 2 treatment groups, lipopolysaccharide (LPS) or saline. Non-surgical (24 month old) mice were also included. Cannulas attached to osmotic pumps were implanted into the lateral ventricles of the brain for 3 weeks. One week after pumps were removed, behavioral testing was performed with the Morris water maze. LPS-treated young (cumulative proximity (cm): 6287 ± 625; RANOVA & Fisher’s LSD) performed significantly worse than saline young (Mean: 4565 ± 352) and similar to old mice (Mean: 7519 ± 389) in reference memory place trials. LPS treated young (average proximity (cm): 40 ± 1.4) performed similar to saline young (35 ± 1.3), and old (45± 1.5) performed the poorest in probe trials for reference memory. LPS didn’t appear to have any effect on reversals, working memory, or cued trials. The average swim speed for reference memory and cued trials showed that the LPS treated were the fastest swimmers, presenting that any deficits were not due to poor motor ability. Stimulating inflammation in a young brain produced only some of the memory deficits seen in aging. Supported by NIH grant AG016322 to K.R.M. Close

• 17. [Article] A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory

  Presentation entitled : A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory / by Emily R. Escobedo and Kathy R. Magnusson

  Citation × Citation Citation Abstract Copy Title: A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory Author: Escobedo, Emily R. Presentation entitled : A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory / by Emily R. Escobedo and Kathy R. Magnusson Title: A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory Author: Escobedo, Emily R. Presentation entitled : A Pro-Inflammatory Agent, Lipopolysaccharide, Can Mimic the Effects of Aging on Spatial Reference Memory / by Emily R. Escobedo and Kathy R. Magnusson Close

• 18. [Article] Youth Recruitment and an Aging Workforce: A Pilot Study of Intergenerational Family Business in Oregon’s Commercial Fishing Industry

  Citation × Citation Citation Abstract Copy Title: Youth Recruitment and an Aging Workforce: A Pilot Study of Intergenerational Family Business in Oregon’s Commercial Fishing Industry Author: Caracciolo, Deanna Title: Youth Recruitment and an Aging Workforce: A Pilot Study of Intergenerational Family Business in Oregon’s Commercial Fishing Industry Author: Caracciolo, Deanna Close

• 19. [Article] Life course perspective : a journey of participation in physical activity

  A life course perspective provide a meta-theoretical framework to understand human development. This perspective is characterized by studying the changing lives within the changing environment (George, ...

  Citation × Citation Citation Abstract Copy Title: Life course perspective : a journey of participation in physical activity Author: Li, Kin-Kit A life course perspective provide a meta-theoretical framework to understand human development. This perspective is characterized by studying the changing lives within the changing environment (George, 2004). Building upon the literature in the psychosocial paradigm and ecological models, Manuscript 1 discusses the uniqueness and the practical importance of a life course perspective for research in physical activity (PA) promotion. The organizing structure of time, together with the paradigmatic principles of a life course perspective, was described within the context of PA. Finally, the implications, methodological issues, and the possibilities of research within the aging population were discussed. Two empirical studies that applied the principles of a life course perspective were used to illustrate its potential use, as well as the substantive implications of the studies. Manuscript 2 presents the first empirical study titled “Life-Threatening Diseases and Physical Activity Trajectories Along the Marriage Life Course: Opportunity or Obstacle?” This study explored the concordance of PA trajectories between husbands and wives and the relationships between life-threatening diseases (LTDs) and PA trajectories using the Panel Study of Income Dynamics. Stable active (SA), activity adopters (AA), activity relapsers (AR), and stable sedentary (SS) were four of the five theoretical PA trajectories developed from the transitional shift patterns in previous research (Levy & Cardinal, 2006), and that were included in the current study. Three relationships were hypothesized including 1) the relationship between wives’ PA trajectories and husbands’ PA trajectories, 2) the curvilinear relationships between husbands’ and wives’ LTD-related limitations and husbands’ PA trajectories, and 3) the interaction effect between age and husbands’ LTD-related limitations on husbands’ PA trajectories. A latent class growth analysis (LCGA) was used to extract the four PA trajectories for husbands and for wives. Results from the LCGA model showed that wives’ PA trajectories were related to husbands’ PA trajectories. Wives’ LTD-related limitations were not associated with husbands’ PA trajectories, while a curvilinear relationship was found for husbands’ LTD-related limitations on being in SA rather than AR. People diagnosed with LTDs with no resulting limitation showed an increased likelihood to be in SA rather than AR for vigorous PA. However, this protective effect declined and became negative with increased LTD-related limitations. The curvilinear relationship was moderated by age. Specifically, younger individuals were more strongly associated with both positive and negative effects of LTD-related limitations compared with older adults. Findings suggested couples and families can be viable intervening units for PA promotion, and that strategies should be tailored to meet the needs of people at different ages during the experience of LTDs. Manuscript 3 presents the second empirical study titled “Change and Continuity of Physical Activity Trajectory at the Transition of Spousal Loss: The Australian Longitudinal Study of Aging.” This study examined 1) whether pre-spousal loss PA trajectories including SA, AA, AR, and SS explained the post-spousal loss PA trajectories, and 2) whether advanced age predicted less favorable post-spousal loss PA trajectories. In addition, the multiple influences of contact with children, spousal care, and depression on the post-spousal loss PA trajectories were also explored. The sample included 930 widowed participants selected from the Australian Longitudinal Study of Aging (ALSA). The pre-spousal loss PA trajectories, age, contact with children, depression, spousal loss, and other covariates were used to predict the membership of the post-spousal loss PA trajectories using sequential LCGA. The pre-spousal loss PA trajectories (ORs=7.90-16.59, ps<.01) and spousal loss (ORs=4.10-4.63, ps<.05) were shown to predict the post-spousal loss PA trajectories. Early intervention aimed at developing habitual PA may prevent the less favorable PA trajectories after spousal loss. For future interventions, the social and environmental factors that may contribute to the changes in the PA trajectories in the transition of spousal loss should continue to be explored. Other life course events and transitions should also receive more attention for PA promotion. Title: Life course perspective : a journey of participation in physical activity Author: Li, Kin-Kit A life course perspective provide a meta-theoretical framework to understand human development. This perspective is characterized by studying the changing lives within the changing environment (George, 2004). Building upon the literature in the psychosocial paradigm and ecological models, Manuscript 1 discusses the uniqueness and the practical importance of a life course perspective for research in physical activity (PA) promotion. The organizing structure of time, together with the paradigmatic principles of a life course perspective, was described within the context of PA. Finally, the implications, methodological issues, and the possibilities of research within the aging population were discussed. Two empirical studies that applied the principles of a life course perspective were used to illustrate its potential use, as well as the substantive implications of the studies. Manuscript 2 presents the first empirical study titled “Life-Threatening Diseases and Physical Activity Trajectories Along the Marriage Life Course: Opportunity or Obstacle?” This study explored the concordance of PA trajectories between husbands and wives and the relationships between life-threatening diseases (LTDs) and PA trajectories using the Panel Study of Income Dynamics. Stable active (SA), activity adopters (AA), activity relapsers (AR), and stable sedentary (SS) were four of the five theoretical PA trajectories developed from the transitional shift patterns in previous research (Levy & Cardinal, 2006), and that were included in the current study. Three relationships were hypothesized including 1) the relationship between wives’ PA trajectories and husbands’ PA trajectories, 2) the curvilinear relationships between husbands’ and wives’ LTD-related limitations and husbands’ PA trajectories, and 3) the interaction effect between age and husbands’ LTD-related limitations on husbands’ PA trajectories. A latent class growth analysis (LCGA) was used to extract the four PA trajectories for husbands and for wives. Results from the LCGA model showed that wives’ PA trajectories were related to husbands’ PA trajectories. Wives’ LTD-related limitations were not associated with husbands’ PA trajectories, while a curvilinear relationship was found for husbands’ LTD-related limitations on being in SA rather than AR. People diagnosed with LTDs with no resulting limitation showed an increased likelihood to be in SA rather than AR for vigorous PA. However, this protective effect declined and became negative with increased LTD-related limitations. The curvilinear relationship was moderated by age. Specifically, younger individuals were more strongly associated with both positive and negative effects of LTD-related limitations compared with older adults. Findings suggested couples and families can be viable intervening units for PA promotion, and that strategies should be tailored to meet the needs of people at different ages during the experience of LTDs. Manuscript 3 presents the second empirical study titled “Change and Continuity of Physical Activity Trajectory at the Transition of Spousal Loss: The Australian Longitudinal Study of Aging.” This study examined 1) whether pre-spousal loss PA trajectories including SA, AA, AR, and SS explained the post-spousal loss PA trajectories, and 2) whether advanced age predicted less favorable post-spousal loss PA trajectories. In addition, the multiple influences of contact with children, spousal care, and depression on the post-spousal loss PA trajectories were also explored. The sample included 930 widowed participants selected from the Australian Longitudinal Study of Aging (ALSA). The pre-spousal loss PA trajectories, age, contact with children, depression, spousal loss, and other covariates were used to predict the membership of the post-spousal loss PA trajectories using sequential LCGA. The pre-spousal loss PA trajectories (ORs=7.90-16.59, ps<.01) and spousal loss (ORs=4.10-4.63, ps<.05) were shown to predict the post-spousal loss PA trajectories. Early intervention aimed at developing habitual PA may prevent the less favorable PA trajectories after spousal loss. For future interventions, the social and environmental factors that may contribute to the changes in the PA trajectories in the transition of spousal loss should continue to be explored. Other life course events and transitions should also receive more attention for PA promotion. Close

• 20. [Article] Escobedo seminar presentation.pdf

  Citation × Citation Citation Abstract Copy Title: Escobedo seminar presentation.pdf Author: Escobedo, Emily R. Title: Escobedo seminar presentation.pdf Author: Escobedo, Emily R. Close