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Regulations
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Author
Breuhahn, Kai
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Author
Kubicka, Stefan
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Author
Schirmacher, Peter
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Singer, Jeffrey D.
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Subject
Cyclin-dependent kinases
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Genetic Phenomena
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Article
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1. [Article] The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells
Cyclin E is often overexpressed in cancer tissue, leading to genetic instability and aneuploidy. Cullin 3 (Cul3) is a component of the BTB-Cul3-Rbx1 (BCR) ubiquitin ligase that is involved in the turnover ...Citation